Category: Aging

Aging Research

How does Therapeutic Plasma Exchange (TPE) make you and your body and mind younger?

/ by Destiny Vandeput

By Dr. Mike Roizen As we stand on the cusp of revolutionary advances in medical science, the quest to understand and potentially reverse the aging process captures the imagination of researchers and the public alike. Among the promising avenues of exploration is therapeutic plasma exchange (TPE), a process that has shown intriguing potential in decreasing […]

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Aging Research

How Plasma Exchange Could Help Turn Back the Clock on Aging

/ by Destiny Vandeput

By Dr. Dobri Kiprov Chief Medical Officer A recent study explored how a procedure called therapeutic plasma exchange (TPE) could slow down the biological aging process. TPE involves removing a person’s blood plasma and replacing it with a plasma substitute, sometimes combined with immunoglobulins (IVIG). The study showed that this procedure not only helps “reset” […]

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Aging Research

Application of biological age assessment of Chinese population in potential anti-ageing technology

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This study aimed to create a biological age assessment formula for the Chinese population and evaluate the effectiveness of double filtration plasmapheresis as an anti-aging intervention. Researchers recruited 915 participants, analyzing 34 blood markers to identify aging biomarkers and develop a biological age formula for both males and females. Double filtration plasmapheresis was then tested […]

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Aging Research

Diluting blood plasma rejuvenates tissue, reverses aging in mice

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UC Berkeley researchers found that diluting the blood plasma of old mice with a saline and albumin solution—without using young blood—rejuvenates tissues in the brain, liver, and muscles. This “neutral blood exchange” lowers harmful, age-associated proteins and allows beneficial proteins to rebound, providing effects similar to or better than young blood transfusions. Key findings include: […]

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Aging Research

Attenuation of age-elevated blood factors by repositioning plasmapheresis: A novel perspective and approach

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This review discusses how aging impairs stem cell activation, leading to tissue decline and an increased risk of age-related diseases. Aging tissues release factors into the bloodstream that can disrupt the function of distant tissues, contributing to degenerative conditions and serving as biomarkers for age-related diseases. The review highlights recent research on reducing these harmful […]

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Aging Research

Study shows that diluting blood plasma ‘resets’ aging

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A study by researchers at UC Berkeley demonstrated that diluting old blood plasma with saline and albumin rejuvenates organs in mice without the need for young blood. This method, which replaces half of the old plasma, improved the health and function of organs like the brain, liver, and muscles by lowering pro-inflammatory proteins associated with […]

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Aging Research

The hope of rejuvenation: using plasma to reverse ageing in mice

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A study by UC Berkeley researchers shows that diluting old mice’s blood plasma with a mixture of saline and albumin (without using young blood) can rejuvenate tissues in organs like the brain, liver, and muscles. This approach, which replaces half of the old plasma with basic components, produced similar or better results than pairing with […]

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Aging Research

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

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This study explores the effects of young blood plasma on aging at the epigenetic level in rats, specifically examining whether plasma treatment can alter the epigenetic clock, a key molecular biomarker of aging. It examines the effects of heterochronic blood exchange (the transfer of blood between young and old mice) on tissue rejuvenation, without the […]

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Aging Research

Reversing age: dual species measurement of epigenetic age with a single clock

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This study explores the effects of young blood plasma on aging at the epigenetic level in rats, specifically examining whether plasma treatment can alter the epigenetic clock, a key molecular biomarker of aging. Researchers developed six epigenetic clocks based on DNA methylation for various rat tissues, including pan-tissue, brain, liver, and blood clocks, as well […]

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Aging Research

Old plasma dilution reduces human biological age: a clinical study

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This study extends findings from animal research on blood heterochronicity to humans, introducing a direct measure of biological age based on changes in 10 specific protein biomarkers. It supports the idea that human aging is driven by an accumulation of systemic molecular imbalances, which can be reduced to reverse biological age. The research shows that […]

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