Research - Lifespan Edge

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Research

Therapeutic Plasma Exchange

/ by Jonathan Vandeput

Therapeutic Plasma Exchange as a Tool for Reversing Age-Related System Dysfunction With A Special Emphasis On Reversing Brain Dysfunction By Patrick Cox, Research Analyst, Lifespan Edge, Inc.   Brief Foreword  By Dr. Michael Roizen & John Mauldin, Co-Founders, Lifespan Edge, Inc.   This brief paper by Patrick Cox does the important job of summarizing thousands […]

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Brain Health Research

Therapeutic Plasma Exchange as a Tool for Reversing Age-Related System Dysfunction With A Special Emphasis On Reversing Brain Dysfunction

/ by Mae Savick

By Patrick Cox, Research Analyst, Lifespan Edge  Brief Foreword  By Dr. Michael Roizen and John Mauldin, Co-Founders, Lifespan Edge   This brief paper by Patrick Cox does the important job of summarizing thousands of pages of significant research introducing the benefits of Therapeutic Plasma Exchange (TPE). It does so by outlining the history of the […]

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Aging Research

How does Therapeutic Plasma Exchange (TPE) make you and your body and mind younger?

/ by Mae Savick

By Dr. Mike Roizen As we stand on the cusp of revolutionary advances in medical science, the quest to understand and potentially reverse the aging process captures the imagination of researchers and the public alike. Among the promising avenues of exploration is therapeutic plasma exchange (TPE), a process that has shown intriguing potential in decreasing […]

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Cancer Research

Revolutionizing Cancer Treatment: Plasma Exchange for Advanced Melanoma

/ by Mae Savick

A new clinical trial, the ReCIPE-M1 study, is exploring an innovative way to treat advanced melanoma (a type of skin cancer) by combining therapeutic plasma exchange (TPE) with existing cancer immunotherapy. The goal is to improve the effectiveness of immunotherapy, which currently works for only about one-third of patients and eventually loses effectiveness for most. […]

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General Research

What’s the Difference Between Plasma Donation and Therapeutic Plasma Exchange (TPE)?

/ by Mae Savick

Plasma donation and TPE are completely different procedures with distinct goals and outcomes. Here’s a clear comparison: Plasma Donation: Plasma donation involves removing a small volume of plasma (typically 500–800 ml) from your body. No replacement fluid is given, as your body naturally replenishes this small loss over time. The primary purpose of plasma donation […]

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Aging Research

How Plasma Exchange Could Help Turn Back the Clock on Aging

/ by Mae Savick

By Dr. Dobri Kiprov Chief Medical Officer A recent study explored how a procedure called therapeutic plasma exchange (TPE) could slow down the biological aging process. TPE involves removing a person’s blood plasma and replacing it with a plasma substitute, sometimes combined with immunoglobulins (IVIG). The study showed that this procedure not only helps “reset” […]

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Inflammation Research

Unlocking Longevity: How Inhibiting IL-11 Could Extend Healthspan and Lifespan

/ by Mae Savick

This study investigates the role of IL-11 signaling in aging and its potential as a therapeutic target to extend healthspan and lifespan in mammals. The researchers demonstrate that inhibiting IL-11 signaling improves multiple age-related health markers and extends lifespan in preclinical models. Key Findings: The findings suggest that targeting IL-11 could provide a novel strategy […]

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Brain Health Research

AMBAR (Alzheimer Management by Albumin Replacement) Study

/ by Unmesh deolekar

The AMBAR (Alzheimer Management by Albumin Replacement) study explored a unique treatment approach that involves removing and replacing a portion of a person’s blood plasma—known as plasma exchange—to see if it might help slow the progression of Alzheimer’s disease. Researchers tested this procedure in people with mild-to-moderate Alzheimer’s, aiming to filter out and replace specific […]

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General Research

Plasma exchange for Guillain-Barré syndrome

/ by Unmesh deolekar | Leave a Comment

This systematic review examines the effectiveness of plasma exchange (PE) in treating Guillain-Barré syndrome, an acute inflammatory condition affecting peripheral nerves that often leads to paralysis. Guillain-Barré syndrome is believed to be caused by autoimmune responses, including harmful antibodies, which PE can help remove from the bloodstream. The procedure involves connecting the patient to a […]

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Brain Health Research

Neuroimaging analyses from a randomized, controlled study to evaluate plasma exchange with albumin replacement in mild‑to‑moderate Alzheimer’s disease: additional results from the AMBAR study

/ by Unmesh deolekar | Leave a Comment

This study, part of the AMBAR phase 2b/3 clinical trial, investigated the effects of therapeutic plasma exchange (PE) with albumin replacement on brain structure and function in patients with mild-to-moderate Alzheimer’s disease (AD). Patients were divided into four groups: three received PE with varying doses of albumin (some with intravenous immunoglobulin, IVIG), while the fourth […]

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Brain Health Research

Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin

/ by Unmesh deolekar | Leave a Comment

This phase 2b/3 trial evaluated the effects of plasma exchange (PE) with albumin replacement on patients with mild-to-moderate Alzheimer’s disease (AD). A total of 347 patients were randomized into three This study challenges the idea that young blood is necessary for tissue rejuvenation, showing instead that “neutral blood exchange” (NBE) — replacing half of an […]

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