Category: Research

Brain Health Research

Plasma Replacement Shows Success in Mild to Moderate Alzheimer Disease

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The AMBAR (Alzheimer Management by Albumin Replacement) study by Grifols demonstrated that plasma exchange (PE) with albumin and immunoglobulin replacement could delay cognitive and functional decline in patients with mild-to-moderate Alzheimer’s disease (AD). Over a 14-month period, 347 patients received PE treatment, which involved six weeks of weekly PE sessions followed by 12 months of […]

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Brain Health Research

Perspective: Is therapeutic plasma exchange a viable option for treating Alzheimer’s disease?

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Therapeutic plasma exchange (TPE) is being explored as a treatment for Alzheimer’s disease (AD) to remove toxic or aging-related factors from the blood. Preclinical studies showed that injecting plasma from young mice into AD mice improved cognitive function, even though it did not reduce brain amyloid plaques. Early clinical trials, including a small study with […]

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Brain Health Research

Emerging insights into the role of albumin with plasma exchange in Alzheimer’s disease management

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Alzheimer’s disease (AD) is a neurodegenerative condition marked by cognitive decline and eventually death. The main pathological features of AD include amyloid-β (Aβ) plaques and neurofibrillary tangles, but oxidative stress and inflammation are also major contributors to AD progression. Current pharmacologic treatments only address symptoms, and many trials targeting amyloid and non-amyloid pathways have failed. […]

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Brain Health Research

Longitudinal lipidomic analyses in patients undergoing therapeutic plasma exchange with albumin replacement as a treatment for Alzheimer’s disease

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This study from the AMBAR trial investigated the effects of plasma exchange with albumin replacement (PE-Alb) on lipidomic profiles in patients with mild-to-moderate Alzheimer’s disease (AD). Since lipid differences are known between AD patients and healthy individuals, this study aimed to see if PE-Alb could impact lipid biomarkers associated with AD. Methodology: Key Findings: Conclusion: […]

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Brain Health Research

Feasibility, safety, and tolerability of two modalities of plasma exchange with albumin replacement to treat elderly patients with Alzheimer’s disease in the AMBAR study

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The AMBAR study examined the feasibility and safety of plasma exchange (PE) with albumin replacement in patients with mild-to-moderate Alzheimer’s disease (AD). Patients received six weeks of weekly therapeutic plasma exchange (TPE) followed by monthly low-volume plasma exchange (LVPE) for 12 months. Key Findings: Conclusion: The TPE and LVPE procedures used in the AMBAR study […]

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Brain Health Research

Inflammatory biomarkers in patients undergoing therapeutic plasma exchange with albumin replacement as a treatment for Alzheimer’s disease

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This study from the AMBAR (Alzheimer Management by Albumin Replacement) phase 2b/3 trial examined the effects of plasma exchange with albumin replacement (PE-Alb) on inflammatory biomarkers in mild-to-moderate Alzheimer’s disease (AD) patients. The goal was to investigate how PE-Alb, which aims to remove neurotoxic amyloid-beta and other pathological substances from the bloodstream, influences inflammation—potentially contributing […]

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Brain Health Research

Neuroimaging analyses from a randomized, controlled study to evaluate plasma exchange with albumin replacement in mild-to-moderate Alzheimer’s disease: additional results from the AMBAR study

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This study, part of the AMBAR phase 2b/3 clinical trial, investigated structural and functional brain changes in Alzheimer’s disease (AD) patients treated with therapeutic plasma exchange (PE) with albumin replacement. The trial included mild-to-moderate AD patients randomized into four groups: three receiving PE with varying doses of albumin (with or without intravenous immunoglobulin, IVIG) and […]

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Brain Health Research

P57 Mapping Quality of Life – Alzheimer’s Disease (QOL-AD) Scores to EQ-5D-5L Utilities in the Ambar Trial Population

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The AMBAR trial assessed the health-related quality of life (HRQoL) impact of plasma exchange with albumin replacement in mild-to-moderate Alzheimer’s disease (AD) patients. Using data from the disease-specific Quality of Life-Alzheimer’s Disease (QoL-AD) questionnaire, EQ-5D-5L utilities were mapped with a model developed by Rombach et al. (2020) to estimate utility values for health economic evaluations. […]

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Brain Health Research

Impact of therapeutic and low volume plasma exchange on clinical laboratory parameters in patients treated for Alzheimer’s disease from the AMBAR study

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The AMBAR trial studied the effects of plasma exchange (PE) on clinical laboratory parameters in Alzheimer’s disease (AD) patients. In this trial, 322 AD patients received six weeks of intensive therapeutic PE (TPE), followed by 12 months of monthly low-volume PE (LVPE). Patients were divided into groups receiving sham PE (placebo), low-dose albumin, low-dose albumin […]

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Brain Health Research

A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer’s disease: Primary results of the AMBAR Study

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This phase 2b/3 trial investigated the effects of plasma exchange (PE) with albumin replacement in patients with mild-to-moderate Alzheimer’s disease (AD). In the study, 347 patients were randomized into three PE treatment groups with varying doses of albumin and intravenous immunoglobulin, or a placebo group. Treatment involved six weeks of weekly conventional PE, followed by […]

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Brain Health Research

Plasma exchange for Alzheimer’s disease Management by Albumin Replacement (AMBAR) trial: Study design and progress

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The AMBAR (Alzheimer Management By Albumin Replacement) study is a multicenter, randomized, placebo-controlled phase IIb/III trial investigating the effects of plasma exchange (PE) with therapeutic albumin replacement in patients with mild to moderate Alzheimer’s disease (AD). Previous studies indicated that PE with albumin may help remove amyloid-beta from plasma and cerebrospinal fluid, leading to improved […]

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Brain Health Research

Results of Grifols’ AMBAR clinical trial published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association

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The results of Grifols’ AMBAR (Alzheimer Management by Albumin Replacement) clinical trial, published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, show that plasma exchange with albumin replacement can slow Alzheimer’s disease progression. The therapy, which removes amyloid-beta protein bound to albumin from the blood, demonstrated benefits in cognitive and functional decline for […]

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