Category: Research

Brain Health Research

Neuropsychological, neuropsychiatric, and quality-of-life assessments in Alzheimer’s disease patients treated with plasma exchange with albumin replacement from the randomized AMBAR study

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The 2021 AMBAR (Alzheimer’s Management by Albumin Replacement) study investigated the effects of plasma exchange (PE) with albumin replacement on neuropsychological, neuropsychiatric, and quality-of-life outcomes in patients with mild-to-moderate Alzheimer’s disease (AD). The study involved 347 patients divided into a placebo group and three PE treatment groups with varying doses of albumin and intravenous immunoglobulin […]

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Brain Health Research

Proof of Concept in the AMBAR Study

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The article presents a proof of concept for an endpoint staging framework applied to the Alzheimer Management by Albumin Replacement (AMBAR) study. This framework aligns clinical trial endpoints (such as cognitive, functional, and quality-of-life measures) to specific Alzheimer’s disease (AD) stages where these outcomes are most relevant. The goal is to improve the sensitivity of […]

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General Research

Guidelines on the Use of Therapeutic Apheresis in Clinical Practice – Evidence-Based Approach from the Writing Committee of the American Society for Apheresis, Volume 38, Issue 2 p. 77-278

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The Ninth Edition of the Journal of Clinical Apheresis (JCA) Special Issue, published by the American Society for Apheresis (ASFA), provides updated guidelines on the use of therapeutic apheresis (TA) in treating human diseases. The edition incorporates a systematic review and evidence-based grading to assess and categorize TA’s use across various medical conditions. Maintaining the […]

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Brain Health Research

Plasma exchange: An effective method to eliminate neurotoxic lipophilic chemicals from blood

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The article discusses plasma exchange (PE) as an effective method for removing neurotoxic lipophilic chemicals, particularly persistent organic pollutants (POPs), from the blood. POPs, which accumulate in human adipose tissue, are neurotoxic and have been linked to dementia risk. These pollutants are continuously released into circulation through lipolysis, posing a risk for individuals with obesity […]

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