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A study by researchers at UC Berkeley demonstrated that diluting old blood plasma with saline and albumin rejuvenates organs in mice without the need for young blood. This method, which replaces half of the old plasma, improved the health and function of organs like the brain, liver, and muscles by lowering pro-inflammatory proteins associated with aging and allowing beneficial proteins to rebound.

The findings suggest that aging-related proteins in old blood, rather than missing factors in young blood, drive age-related decline. This approach could lead to human therapies that utilize therapeutic plasma exchange to reduce aging effects without relying on young blood transfusions. Clinical trials are planned to investigate its potential for human applications.