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This systematic review examines the effectiveness of plasma exchange (PE) in treating Guillain-Barré syndrome, an acute inflammatory condition affecting peripheral nerves that often leads to paralysis. Guillain-Barré syndrome is believed to be caused by autoimmune responses, including harmful antibodies, which PE can help remove from the bloodstream. The procedure involves connecting the patient to a machine that exchanges their plasma for a substitute solution, usually albumin.

Objectives and Methodology:

• The review aimed to evaluate the efficacy of PE in Guillain-Barré syndrome by analyzing data from randomized and quasi-randomized trials comparing PE to sham or supportive treatments.
• The Cochrane Neuromuscular Disease Trial Register was searched for relevant trials, and references from identified papers were also reviewed.
• Two reviewers independently selected eligible studies, with data extracted by one reviewer and verified by another.

This systematic review represents a comprehensive analysis of available evidence on the benefits of plasma exchange for Guillain-Barré syndrome, supporting its role in reducing disease progression and severity.