Brain Health Research Impact of therapeutic and low volume plasma exchange on clinical laboratory parameters in patients treated for Alzheimer’s disease from the AMBAR study November 6, 2024 / June 13, 2025 by Unmesh deolekar | Leave a Comment The AMBAR trial studied the effects of plasma exchange (PE) on clinical laboratory parameters in Alzheimer’s disease (AD) patients. In this trial, 322 AD patients received six weeks of intensive therapeutic PE (TPE), followed by 12 months of monthly low-volume PE (LVPE). Patients were divided into groups receiving sham PE (placebo), low-dose albumin, low-dose albumin […] Read more Alzheimers Disease AMBAR AMBAR Study Apheresis biotech Grifols therapeutic plasma exchange tpe
Brain Health Research A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer’s disease: Primary results of the AMBAR Study November 6, 2024 / June 13, 2025 by Unmesh deolekar | Leave a Comment This phase 2b/3 trial investigated the effects of plasma exchange (PE) with albumin replacement in patients with mild-to-moderate Alzheimer’s disease (AD). In the study, 347 patients were randomized into three PE treatment groups with varying doses of albumin and intravenous immunoglobulin, or a placebo group. Treatment involved six weeks of weekly conventional PE, followed by […] Read more Alzheimers Disease AMBAR AMBAR Study Apheresis biotech Grifols therapeutic plasma exchange tpe
Brain Health Research Plasma exchange for Alzheimer’s disease Management by Albumin Replacement (AMBAR) trial: Study design and progress November 6, 2024 / June 13, 2025 by Unmesh deolekar | Leave a Comment The AMBAR (Alzheimer Management By Albumin Replacement) study is a multicenter, randomized, placebo-controlled phase IIb/III trial investigating the effects of plasma exchange (PE) with therapeutic albumin replacement in patients with mild to moderate Alzheimer’s disease (AD). Previous studies indicated that PE with albumin may help remove amyloid-beta from plasma and cerebrospinal fluid, leading to improved […] Read more Alzheimers Disease AMBAR AMBAR Study Apheresis biotech Grifols therapeutic plasma exchange tpe
Brain Health Research Results of Grifols’ AMBAR clinical trial published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association November 6, 2024 / June 13, 2025 by Unmesh deolekar | Leave a Comment The results of Grifols’ AMBAR (Alzheimer Management by Albumin Replacement) clinical trial, published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, show that plasma exchange with albumin replacement can slow Alzheimer’s disease progression. The therapy, which removes amyloid-beta protein bound to albumin from the blood, demonstrated benefits in cognitive and functional decline for […] Read more Alzheimers Disease AMBAR AMBAR Study Apheresis biotech Grifols therapeutic plasma exchange tpe
