General Research What’s the Difference Between Plasma Donation and Therapeutic Plasma Exchange (TPE)? December 31, 2024 / June 13, 2025 by Destiny Vandeput Plasma donation and TPE are completely different procedures with distinct goals and outcomes. Here’s a clear comparison: Plasma Donation: Plasma donation involves removing a small volume of plasma (typically 500–800 ml) from your body. No replacement fluid is given, as your body naturally replenishes this small loss over time. The primary purpose of plasma donation […] Read more donating plasma dr. dobri kiprov plasma therapeutic plasma exchange tpe