Tag: therapeutic plasma exchange

Aging Research

Attenuation of age-elevated blood factors by repositioning plasmapheresis: A novel perspective and approach

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This review discusses how aging impairs stem cell activation, leading to tissue decline and an increased risk of age-related diseases. Aging tissues release factors into the bloodstream that can disrupt the function of distant tissues, contributing to degenerative conditions and serving as biomarkers for age-related diseases. The review highlights recent research on reducing these harmful […]

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Brain Health Research

Plasma dilution improves cognition and attenuates neuroinflammation in old mice

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This study reveals that “neutral blood exchange” (NBE)—a procedure that dilutes old blood plasma without adding young blood factors—can rejuvenate tissues and improve brain function in aged mice. Unlike young blood infusions, NBE resets the body’s signaling environment, enhancing muscle and liver repair, hippocampal neurogenesis, and cognitive performance in older mice. Key findings include: These […]

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Aging Research

Study shows that diluting blood plasma ‘resets’ aging

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A study by researchers at UC Berkeley demonstrated that diluting old blood plasma with saline and albumin rejuvenates organs in mice without the need for young blood. This method, which replaces half of the old plasma, improved the health and function of organs like the brain, liver, and muscles by lowering pro-inflammatory proteins associated with […]

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Aging Research

The hope of rejuvenation: using plasma to reverse ageing in mice

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A study by UC Berkeley researchers shows that diluting old mice’s blood plasma with a mixture of saline and albumin (without using young blood) can rejuvenate tissues in organs like the brain, liver, and muscles. This approach, which replaces half of the old plasma with basic components, produced similar or better results than pairing with […]

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Aging Research

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

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This study explores the effects of young blood plasma on aging at the epigenetic level in rats, specifically examining whether plasma treatment can alter the epigenetic clock, a key molecular biomarker of aging. It examines the effects of heterochronic blood exchange (the transfer of blood between young and old mice) on tissue rejuvenation, without the […]

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Aging Research

Reversing age: dual species measurement of epigenetic age with a single clock

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This study explores the effects of young blood plasma on aging at the epigenetic level in rats, specifically examining whether plasma treatment can alter the epigenetic clock, a key molecular biomarker of aging. Researchers developed six epigenetic clocks based on DNA methylation for various rat tissues, including pan-tissue, brain, liver, and blood clocks, as well […]

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Aging Research

Old plasma dilution reduces human biological age: a clinical study

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This study extends findings from animal research on blood heterochronicity to humans, introducing a direct measure of biological age based on changes in 10 specific protein biomarkers. It supports the idea that human aging is driven by an accumulation of systemic molecular imbalances, which can be reduced to reverse biological age. The research shows that […]

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Brain Health Research

Complementary analyses of the AMBAR trial: Impact of discontinuations, consistency of results across outcomes and additional adjustments

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The AMBAR study analyzed the effects of plasma exchange (PE) with albumin (with or without intravenous immunoglobulin, IVIG) on mild-to-moderate Alzheimer’s disease (AD) patients. Of the 496 patients enrolled, 347 were randomized into three treatment groups (different doses of albumin and IVIG) and a placebo group. Results showed that PE slowed cognitive and functional decline […]

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Brain Health Research

Plasma Replacement Shows Success in Mild to Moderate Alzheimer Disease

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The AMBAR (Alzheimer Management by Albumin Replacement) study by Grifols demonstrated that plasma exchange (PE) with albumin and immunoglobulin replacement could delay cognitive and functional decline in patients with mild-to-moderate Alzheimer’s disease (AD). Over a 14-month period, 347 patients received PE treatment, which involved six weeks of weekly PE sessions followed by 12 months of […]

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Brain Health Research

Perspective: Is therapeutic plasma exchange a viable option for treating Alzheimer’s disease?

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Therapeutic plasma exchange (TPE) is being explored as a treatment for Alzheimer’s disease (AD) to remove toxic or aging-related factors from the blood. Preclinical studies showed that injecting plasma from young mice into AD mice improved cognitive function, even though it did not reduce brain amyloid plaques. Early clinical trials, including a small study with […]

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Brain Health Research

Emerging insights into the role of albumin with plasma exchange in Alzheimer’s disease management

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Alzheimer’s disease (AD) is a neurodegenerative condition marked by cognitive decline and eventually death. The main pathological features of AD include amyloid-β (Aβ) plaques and neurofibrillary tangles, but oxidative stress and inflammation are also major contributors to AD progression. Current pharmacologic treatments only address symptoms, and many trials targeting amyloid and non-amyloid pathways have failed. […]

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Brain Health Research

Longitudinal lipidomic analyses in patients undergoing therapeutic plasma exchange with albumin replacement as a treatment for Alzheimer’s disease

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This study from the AMBAR trial investigated the effects of plasma exchange with albumin replacement (PE-Alb) on lipidomic profiles in patients with mild-to-moderate Alzheimer’s disease (AD). Since lipid differences are known between AD patients and healthy individuals, this study aimed to see if PE-Alb could impact lipid biomarkers associated with AD. Methodology: Key Findings: Conclusion: […]

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